Polypeptide drugs are usually formed by separation and purification of 10-100 amino acid molecules after dehydration. Polypeptide drugs have the advantages of strong specificity, low immunogenicity, not easy to accumulate in the body, less interaction with other drugs, and good affinity with receptors in the body, etc., and occupy an important position in the medical industry. It is expected that more domestic pharmaceutical companies will emerge in the future and stand out in the research and development of peptide drugs.DMF (N, N-dimethylformamide) is an excellent universal solvent. In the production of polypeptide drugs, the specific role of DMF is mainly reflected in the following aspects: 1. Solvent action: DMF is an excellent solvent that can dissolve a variety of organic and inorganic compounds, so in the synthesis of polypeptide drugs, DMF is often used as a reaction solvent to help the reactants fully mix and react. 2, promote the reaction: In peptide synthesis, DMF can promote the reaction by interacting with the reactants to form hydrogen bonds, thus accelerating the generation of polypeptide chains. 3, washing and removal of protective groups: In the post-processing of peptide synthesis, DMF is also often used as a washing solvent to help remove unreacted reactants and byproducts. In addition, DMF can also be used to remove protective groups from the polypeptide chain to obtain the target polypeptide.
At present, China's population base is large, aging is increasing, there are a large number of patients with diabetes, cancer and chronic diseases, China's polypeptide drugs for diabetes, cancer, rare diseases and other products account for a relatively small proportion, the market is far from saturated, with the rapid rise of peptide pharmaceutical enterprises in China in recent years and the continuous increase of research and development investment, peptide drugs in the future there is a large room for growth.
Shandong Desenlai currently has two production bases in Dezhou and Jingzhou, and has been deeply engaged in the DMF industry for more than 20 years. As one of the main manufacturers of DMF in China, it has excellent product quality and extensive channel coverage, and has become the preferred supplier for domestic polypeptide drug users. We will always adhere to the "customer first choice" business philosophy, to quality products, stable supply, efficient service, to create a sustainable and stable business partnership and make unremitting efforts
