DMF Emerging Medicine Downstream - Polypeptide Drugs

Polypeptide drugs are usually formed by separation andpurification of 10-100 amino acid molecules afterdehydration.Polypeptide drugs have the advantages ofstrong specificity, low immunogenicity, not easy toaccumulate in the body, less interaction with other drugsand good affinity with receptors in the body, etc., andoccupy an important position in the medical industry. lt isexpected that more domestic pharmaceutical companieswill emerge in the future and stand out in the research anddevelopment of peptide drugs.

DMF(N, N-dimethylformamide) is an excellent universalsolvent. In the production of polypeptide drugs, thespecific role of DMF is mainly reflected in the followingaspects:1.Solvent action: DMF is an excellent solvent thatcan dissolve a variety of orqanic and inorganic compoundsso in the synthesis of polypeptide drugs, DMF is often usedas a reaction solvent to help the reactants fully mix andreact. 2, promote the reaction:In peptide synthesis, DMFcan promote the reaction by interacting with the reactantsto form hydrogen bonds, thus accelerating the generationof polypeptide chains. 3, washing and removal ofprotective groups: In the post-processing of peptidesynthesis, DMF is also often used as a washing solvent tohelp remove unreacted reactants and byproducts. Inaddition, DMF can also be used to remove protectivegroups from the polypeptide chain to obtain the targetpolypeptide.

At present, China's population base is large, aging isincreasing, there are a large number of patients withdiabetes, cancer and chronic diseases, China's polypeptidedrugs for diabetes, cancer, rare diseases and otherproducts account for a relatively small proportion, themarket is far from saturated, with the rapid rise of peptidepharmaceutical enterprises in China in recent years and thecontinuous increase of research and developmentinvestment, peptide drugs in the future there is a largeroom for growth.