gamma-butyrolactone (GBL) downstream products do you know what?

Let's take a look at the main downstream products of GBL

(1) N-methylpyrrolidone (NMP)

It is obtained by the condensation of gamma-butyllactone and methylamine. As a highly selective solvent, the product is mainly used to extract acetylene, extract butadiene, isoprene, and extract aromatics from lubricating oil distillates to improve the quality of lubricating oil, especially as an environmentally friendly non-toxic solvent and electrolyte of lithium batteries. As a resin processing solvent for the manufacture of a variety of vinyl coatings; As the solvent of polymerization reaction, it is used to manufacture polyimide heat-resistant resin, polyamide, polyphenyl ether, etc. In addition, it can also synthesize fine chemicals such as medicine, pigment, fragrance and cleaning agent.

(2) Cyclopropylamine (CPA)

It is an important fatty amine containing three rings, mainly used in medicine, pesticides, fine chemical synthesis, etc., especially in medicine, the use of large, mainly synthesis of ciprofloxacin, anthrafloxacin, Sparfloxacin, ciprofluronic acid, etc.

γ-butylactone as raw material, synthesis steps are divided into five - step method and three - step method, the three - step method is more compact and advanced. Several large CPA companies abroad all use gamma-butyrolactone as raw material production. The research on CPA in China started relatively late, but now the domestic research and development is gradually mature and has the conditions for industrialization. There are mainly China Medical University, Tianjin Central Pharmaceutical Factory, Northeast Pharmaceutical General Factory, Zhejiang University, etc. The industrialization production was first realized by the open source chemical plant in Zhejiang University. In recent years, the third-generation quinolone antibacterial drugs showing strong antibacterial activity against staphylococcus and pseudomonas aeroginosa have been rapidly developed in foreign countries, among which ciprofloxacin (ciprofloxacin) and ciprofluronic acid are both produced with CPA as raw materials, and the demand for CPA is growing rapidly.

At present, our CPA production enterprises mainly include Zhejiang Shaxing Pharmaceutical and Chemical Company, Zhejiang Haixiang Pharmaceutical and Chemical Company, Xinchang Guobang Chemical Industry Company, Xi 'an Rehabilitation Pharmaceutical Factory, Hangzhou Xingyuan Science and Technology Industrial Company, Yangzhou Xingda Chemical Company, Huainan Third Pharmaceutical Factory and Jiangxi Province Pingxiang Mulberry Forest Chemical Factory.

(3) 2-pyrrolidone (α-pyrrolidone), n-vinylpyrrolidone (NVP) and polyethylpyrrolidone (PVP)

By γ-butyrolactone as raw material, ammoniation and 2-pyrrolidone, the product is nylon -4 monomer, plasticizer, polymer intermediate, can produce medical brain and aminoacid;

Using 2-pyrrolidone as raw material through the formation of potassium salt and dehydration, in acetylene ethylene reaction to obtain N-vinylpyrrolidone, the product is mainly used for the synthesis of polyethylpyrrolidone; Polyvinylpyrrolidone (PVP) for short, has excellent solubility, film formation, complexation, surface activity and chemical stability, is an important polymer product, usually according to the average molecular weight of different and different uses. Mainly used in medicine, food, daily chemical, coating, polymer polymerization, paper making, textile printing and dyeing, photographic materials, agriculture and other fields. The production and application of PVP started relatively late in our country, with few manufacturers mainly relying on imports. With the rapid demand of povidone iodine, food clarifying agent and moisturizing agent for daily cosmetics in China, the prospect of PVP development is extremely broad.

(4) 2-pyrrolidone 5-carboxylic acid

It is prepared from -carboxylic acid and gamma-butylactone by esterification, ammonification, cyclization, decompression heating and deamination. This product has three kinds of optically active isomers, mainly in the form of esters and salts, widely used in daily chemical, paper, leather, textile, medicine and food and other fields, there is no domestic production equipment, so the application is very limited.

(5) glutaric acid

From γ-butylactone as raw material, reaction with potassium cyanide, adding hydrochloric acid acidification to get glutaric acid monoamide, then heating hydrolysis to get glutaric acid. This product is mainly used as the initiator of synthetic resin, rubber and polymer and the curing agent of epoxy resin. At present, only a few domestic enterprises produce glutaric anhydride. With the rapid increase of the production of synthetic resin and epoxy resin, the domestic demand for glutaric anhydride increases rapidly.

(6) alpha-acetyl-gamma-butyrolactone (ABL)

This product is obtained by the multi-step reaction of GBL and methyl acetoacetate. It is an important fine chemical intermediate. Nantong Acetic Acid Chemical Co., LTD is the main manufacturer of this product, which is mainly used for the synthesis of vitamin B1, pesticide and medicine. Vitamin B1 is one of the three major vitamin varieties in the world at present, and our country is a major producer and exporter.

(7) gamma-hydroxybutyric acid

By gamma-butylactone hydrolysis, gamma-hydroxybutyrate is mainly used as a general anesthetic gamma-hydroxybutyrate sodium, often used in general anesthesia or induced anesthesia, as well as local anesthesia, auxiliary drugs of lumbar anesthesia, suitable for the elderly, children and brain, neurosurgery, trauma, burn patients anesthesia, is a very promising market anesthetic. In addition, it can be used as a special plasticizer for synthetic resin.

(8) succinic acid

Obtained by the oxidation of γ-butylactone, succinic acid is an important petrochemical raw material, used in the pharmaceutical industry for the production of sedatives, diuretics, antipyretic analgesics, contraception and cancer drugs; Succinate ester and salt, can be used for the synthesis of dyes, alkyd resins, vinyl resins, adhesives and rubber plasticizers, ion exchange resins, a variety of pesticides and fine chemical intermediates N, n-diethyl-n-propyl succinamide, etc.; Succinic acid and its sodium salt are used as food flavoring agent and flavoring agent.

(9) 2-bromo-chloro-butyrolactone

Gamma-butyrolactone can be obtained through different halogenated agents 2-bromo-butyl lactone, 2-bromo-butyl lactone is an important pesticide raw material, can be respectively and 3-chloro-2, 6-dimethylaniline, 2, 6-dimethylaniline synthesis fungicide antimycin, furamide and furamide, etc., these fungicides are new promising products. 2-chloro-butyrolactone has not been produced in China, and it is mainly used in the production of new drugs.

With the continuous development of the related industries, the demand for gamma-butylactone (GBL) in the above other areas will continue to grow, especially in medicine, pesticides, spices, artificial plasma and the preparation of vitamins and chlorophyll and other aspects, the prospect is promising, will become the new growth point of demand for GBL.

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